Biological properties of trabecular meshwork cells
نویسندگان
چکیده
منابع مشابه
sCD44 internalization in human trabecular meshwork cells.
PURPOSE To determine whether soluble CD44 (sCD44), a likely biomarker of primary open-angle glaucoma (POAG), is internalized in cultured human trabecular meshwork (TM) cells and trafficked to mitochondria. METHODS In vitro, 32-kD sCD44 was isolated from human sera, biotinylated, and dephosphorylated. TM cells were incubated for 1 hour at 4°C with biotinylated albumin (b-albumin), biotin-label...
متن کاملHyaluronan synthase in trabecular meshwork cells.
BACKGROUND/AIMS Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated. METHODS Cultured bovine trabecular meshwork cells (BTMCs) were used. HAS expression in...
متن کاملInduction of trabecular meshwork cells from induced pluripotent stem cells.
PURPOSE Loss or dysfunction of trabecular meshwork (TM) cells has been associated with the development of pathologically elevated IOP, and it is conceivable that replacement of damaged TM cells could restore function to the TM. We propose that the use of TM-like cells derived from induced pluripotent stem cells (iPSCs) created from a patient's own dermal fibroblasts offers the best solution to ...
متن کاملCalf Trabecular Meshwork
Superoxide dismutase and catalase activities have been measured in cell-free extracts of calf trabecular meshwork, and for comparison, in calf iris, retina, lens, liver, and erythrocytes. Gel electrophoresis has been used to identify isozymes of each enzyme. The superoxide dismutase and catalase activities per milligram wet weight of calf trabecular meshwork, 0.184 and 0.884 U/mg wet wt, respec...
متن کاملCB1 cannabinoid receptor-mediated changes of trabecular meshwork cellular properties.
PURPOSE To evaluate the roles of CB1 cannabinoid receptors in cellular functions of trabecular meshwork (TM) cells, including cell migration, adhesion, morphology and cytoskeleton changes. METHODS Noladin ether, a selective CB1 receptor agonist, and SR141716A, a selective CB1 receptor antagonist, were used to characterize the cellular functions of cultured porcine TM cells. Fluorescence assis...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2009
ISSN: 0014-4835
DOI: 10.1016/j.exer.2008.08.006